What Is 3-(Hydroxymethyl)phenylboronic Acid CAS 87199-15-3 Used For?

3-(Hydroxymethyl)phenylboronic acid, CAS 87199-15-3, is primarily used as a multifunctional building block in medicinal chemistry, pharmaceutical intermediate development, and small-molecule synthesis. Its boronic acid group can participate in palladium-catalyzed Suzuki–Miyaura coupling, while its hydroxymethyl group provides a separate alcohol handle for further derivatization. I supply this compound as a research and synthesis intermediate for teams that need to introduce a substituted benzene ring and retain an additional functional group for later process steps.

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The compound is commonly identified by the molecular formula C₇H₉BO₃ and an approximate molecular weight of 151.96 g/mol. Because the exact commercial specification can vary by grade, packaging, and analytical method, I recommend confirming identity, assay, water content, and impurity limits before purchase. Its most suitable use is as a controlled-input intermediate rather than as a finished active pharmaceutical ingredient.

Core Functions of 3-(Hydroxymethyl)phenylboronic Acid

Suzuki–Miyaura Coupling Building Block

The most important synthetic function of this material is the aryl boronic acid group. In a Suzuki–Miyaura reaction, the boronic acid can be coupled with an appropriate aryl or heteroaryl halide to form a new carbon–carbon bond. This makes CAS 87199-15-3 useful when a synthesis requires a benzene ring carrying a hydroxymethyl substituent and a newly installed aromatic or heteroaromatic group.

Reaction performance depends on the selected catalyst, base, solvent, temperature, substrate compatibility, and work-up conditions. I therefore treat the compound as a reaction-specific intermediate rather than promising identical conversion in every process. Buyers should validate the intended coupling using their own substrate and process conditions.

Orthogonal Functionalization Through the Hydroxymethyl Group

The hydroxymethyl group provides a second point for chemical modification. Depending on the target structure, it may be converted into an ether, ester, halide, aldehyde, or other derivative through an appropriate synthetic route. This combination of a boronic acid and a primary alcohol gives chemists flexibility when planning sequential or convergent synthesis.

The order of functionalization matters. Some reaction conditions that are suitable for the boronic acid may affect the alcohol, while strong oxidation, strongly acidic environments, or prolonged exposure to incompatible conditions may reduce material quality. I recommend evaluating protecting-group requirements and reaction compatibility during route design rather than assuming that both functional groups will remain unchanged under all conditions.

Where Is CAS 87199-15-3 Used?

Pharmaceutical and Medicinal Chemistry Research

Pharmaceutical researchers may use 3-(Hydroxymethyl)phenylboronic acid to prepare analogues during hit expansion, lead optimization, or route exploration. The boronic acid enables rapid aromatic diversification, while the hydroxymethyl substituent can be retained as part of the target molecule or transformed into another pharmacophore. This is particularly relevant when a project needs a substituted benzyl alcohol motif within a more complex scaffold.

Use in pharmaceutical research does not mean that the material itself is an approved drug substance or suitable for direct formulation. It is a chemical intermediate intended for further synthesis and characterization. Final suitability depends on the customer’s route, analytical controls, toxicological assessment, and regulatory requirements.

Heteroaryl and Biaryl Compound Synthesis

The compound can be considered when researchers need to connect a hydroxymethyl-substituted phenyl unit with a heteroaryl or aryl partner. Such transformations are frequently explored in the preparation of screening compounds, reference standards, and advanced intermediates. The exact product range depends on the halide or pseudohalide selected for the coupling reaction.

Before scale-up, I recommend checking substrate solubility, catalyst loading, base selection, and the ease of removing residual palladium or boron-containing by-products. A reaction that performs well at milligram scale may require a different isolation strategy at gram or kilogram scale. Process development should therefore include impurity profiling and recovery considerations.

Linker and Derivative Development

The hydroxymethyl group can serve as a practical attachment point in the preparation of linkers, conjugated intermediates, and multifunctional aromatic molecules. Researchers may use it to introduce polarity, connect the aromatic ring to another fragment, or build a more extended molecular architecture. The boronic acid group can be used before or after this modification, depending on the desired synthetic sequence.

With competitive price and timely delivery, Maison Chemical sincerely hope to be your supplier and partner.

For linker development, the main value is structural flexibility rather than a single defined application. The appropriate route will depend on whether the project prioritizes a free alcohol, an activated derivative, or a protected intermediate. I can discuss the intended transformation so that the requested grade and packaging are aligned with the route.

Material and Specification Considerations

Commercial buyers should distinguish between chemical identity and release specification. CAS 87199-15-3 identifies the substance, but it does not by itself define assay, water content, residual solvents, particle characteristics, or packaging requirements. For a purchasing decision, I suggest reviewing the certificate of analysis, analytical method, batch information, and storage guidance supplied for the specific lot.

For a new project, a buyer may begin with a laboratory quantity such as 10 g or 100 g for route screening, then request a larger package after the reaction and isolation method are confirmed. These quantities are planning examples, not a guaranteed stock commitment. I recommend requesting current availability, minimum order quantity, lead time, and packaging options for the required batch size.

How I Help Buyers Select the Right Supply Option

Match the Grade to the Project Stage

Early discovery work may focus on identity, usable assay, and rapid availability, while process development usually requires tighter control of impurities, documentation, and batch-to-batch consistency. For regulated or late-stage programs, buyers may also need defined specifications, traceability, controlled change communication, and a documented quality system. The correct specification should follow the project stage rather than relying only on the lowest purchase price.

Check Route Compatibility Before Ordering Larger Quantities

I recommend sharing the intended reaction type, approximate consumption, target delivery schedule, and any special documentation requirements during the inquiry stage. If the compound will be used in a Suzuki coupling, relevant questions may include catalyst compatibility, expected assay basis, water limits, and the customer’s purification method. This information helps reduce the risk of ordering a material that is chemically correct but operationally unsuitable.

Buyers should also confirm whether the material is supplied as a neat compound or under any specific packaging and handling arrangement. Storage conditions, shipping regulations, and local import requirements should be reviewed before dispatch. I can provide project-oriented commercial information, but the customer remains responsible for validating the compound in its own process.

Why Work With Maison Chemical?

At Maison Chemical, I support customers seeking 3-(Hydroxymethyl)phenylboronic acid CAS 87199-15-3 for pharmaceutical intermediate and specialty chemical applications. My role is to connect the requested structure with practical supply details, including specification review, packaging discussion, batch availability, and export coordination. I do not treat one standard specification as suitable for every customer; the project requirement should guide the quotation.

For repeat demand, I can help establish a clearer purchasing plan around forecast volume, delivery windows, and documentation needs. For new routes, I can first support a smaller evaluation quantity before the buyer commits to a larger order. Any statement about purity, lead time, or available stock should be confirmed against the current lot and quotation.

Key Takeaways

• 3-(Hydroxymethyl)phenylboronic acid CAS 87199-15-3 is mainly used as a multifunctional synthetic building block.
• Its boronic acid group supports Suzuki–Miyaura carbon–carbon coupling with suitable aryl or heteroaryl partners.
• Its hydroxymethyl group can be retained or converted into other functional derivatives.
• Common development areas include medicinal chemistry, pharmaceutical intermediates, biaryl compounds, heteroaryl compounds, and linker research.
• Identity alone is not enough for procurement; assay, impurities, water content, packaging, storage, and documentation should also be confirmed.

Conclusion and Next Steps

In direct answer to the question, 3-(Hydroxymethyl)phenylboronic acid CAS 87199-15-3 is used to introduce a hydroxymethyl-substituted phenyl unit into more complex molecules, especially through Suzuki coupling and subsequent alcohol functionalization. It is valuable when a synthesis requires two independently useful reaction handles in one aromatic intermediate. Its actual performance must still be confirmed in the customer’s specific route.

If you are evaluating this compound, I suggest preparing the target quantity, desired assay or impurity limits, intended application, packaging preference, and required delivery date. Send these details to Maison Chemical for a current quotation and supply review. I can then help identify a practical option for laboratory evaluation, process development, or repeat pharmaceutical intermediate procurement.

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