2-Chlorophenylboronic acid CAS 3900-89-8: Uses, Specifications, and Supplier Guide

2-Chlorophenylboronic acid, CAS 3900-89-8, is an aryl boronic acid used mainly as a building block in palladium-catalyzed cross-coupling, especially Suzuki–Miyaura reactions. Its key value is the combination of a boronic acid functional group, which enables carbon–carbon bond formation, and an ortho-chloro substituent, which can remain available for further chemical transformation. The compound has the molecular formula C₆H₆BClO₂ and a calculated molecular weight of approximately 156.37 g/mol. I recommend evaluating it through identity, assay, water, residual solvent, packaging, and batch documentation rather than relying on the CAS number alone.

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Key Takeaways for Buyers

• 2-Chlorophenylboronic acid is primarily a synthetic intermediate for pharmaceutical, agrochemical, and fine-chemical research.
• Its approximate molecular weight is 156.37 g/mol, based on the stated molecular formula.
• The most important purchasing documents are a current specification sheet, certificate of analysis, safety data sheet, and shipment-specific quality information.
• Reaction performance can depend on purity, moisture exposure, catalyst system, base, solvent, and storage conditions.
• Maison Chemical can support buyer discussions around product documentation, packaging, quantity requirements, and export coordination, subject to project-specific confirmation.

What Is 2-Chlorophenylboronic Acid?

2-Chlorophenylboronic acid is an aromatic boronic acid in which a boronic acid group is attached to a chlorinated benzene ring. The “2-chloro” designation means that the chlorine atom is positioned ortho to the boronic acid group on the aromatic ring. This structure gives synthetic chemists two useful handles: the boronic acid can participate in cross-coupling, while the aryl chloride may be retained for later modification depending on the reaction design.

In procurement terms, CAS 3900-89-8 identifies the substance, but it does not by itself define commercial grade, assay, physical form, particle size, packaging, or shelf life. I therefore treat the CAS number as an identity reference and request batch-specific documentation before approving material for a development or manufacturing program. Buyers should also confirm whether the required grade is intended for research use, process development, or a regulated application.

Uses and Application Scenarios

Suzuki–Miyaura Cross-Coupling

The principal use of 2-chlorophenylboronic acid is as an aryl donor in Suzuki–Miyaura coupling. Under a suitable catalyst, base, solvent, and temperature profile, the boronic acid group can be coupled with an appropriate aryl or vinyl halide to create a new carbon–carbon bond. This makes the material useful for preparing substituted biaryl structures that appear in medicinal chemistry and advanced intermediate synthesis.

Reaction outcomes are not determined by the boronic acid alone. Catalyst loading, ligand selection, substrate electronics, base compatibility, water content, and work-up conditions can all influence conversion and impurity formation. For this reason, I recommend treating supplier material as one part of a broader process-development package rather than assuming that a nominal assay guarantees identical performance in every reaction.

Pharmaceutical and Agrochemical Intermediates

Researchers may use this intermediate when they need to introduce a 2-chlorophenyl fragment into a more complex molecule. The chlorine substituent can provide a defined electronic and steric effect, or it may serve as a separate transformation site in a multi-step route. The final suitability depends on the target structure, route sequence, regulatory requirements, and impurity-control strategy.

Medicinal Chemistry and Custom Synthesis

Small-scale discovery programs often require multiple aryl boronic acids for rapid analogue preparation. 2-Chlorophenylboronic acid can be considered when a project needs a chlorinated aromatic fragment combined with a coupling-ready boronic acid. For custom synthesis, I suggest confirming available pack sizes and realistic replenishment timing before selecting it as a recurring route input.

Specifications Buyers Should Review

A reliable specification review should cover both chemical identity and practical handling information. Common specification categories include appearance, identification, assay, related substances, water content, residual solvents, and inorganic residue, although the exact limits should be agreed with the supplier and matched to the application. The product’s formula is C₆H₆BClO₂, and its approximate molecular weight is 156.37 g/mol.

I do not recommend using an unsupported universal assay value or shelf-life claim for every supplier. Commercial limits can differ by grade, analytical method, and intended use. A buyer should request a current certificate of analysis for the exact lot, and should compare the reported results with the internal release criteria for the project.

How to Select the Right Supply Option

Step 1: Define the Intended Use

First, I identify whether the material is for route scouting, medicinal chemistry, process development, or routine production. A discovery team may prioritize small quantities and rapid documentation, while a manufacturing buyer may place greater weight on lot consistency, change notification, packaging qualification, and supply continuity. The same chemical name can therefore require different purchasing controls.

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Step 2: Establish the Required Quality Profile

Next, I compare the buyer’s requirements for assay, impurity limits, water, residual solvents, and analytical methods with the supplier’s available specification. If the application is sensitive to trace impurities, I request additional chromatographic or analytical information before placing a larger order. Buyers should also clarify whether the supplier can provide representative data, batch-specific data, or only a general product specification.

Step 3: Confirm Quantity, Packaging, and Timing

Quantity should be discussed together with packaging and delivery expectations. A small research pack, a development quantity, and a recurring production order may involve different packaging configurations and lead-time assumptions. I recommend requesting a written quotation that states quantity, package size, Incoterms if applicable, documentation, estimated lead time, and any minimum order requirement.

Step 4: Review Safety and Storage Information

Before use, the receiving team should review the supplier’s safety data sheet and handling instructions. Storage conditions should follow the applicable SDS and product label, with attention to container closure, moisture exposure, temperature, and segregation requirements. The end user remains responsible for assessing hazards in its own process, including solvent, catalyst, reaction-temperature, and scale-related risks.

Common Purchasing Mistakes

One common mistake is selecting solely by the lowest quoted price. A lower unit price may not represent the lowest total cost if documentation is incomplete, packaging is unsuitable, or additional testing is required after receipt. I also advise buyers not to assume that two lots with the same CAS number will have identical impurity profiles without reviewing their certificates of analysis.

Another mistake is ignoring the difference between theoretical molecular weight and practical assay. The approximate molecular weight of 156.37 g/mol is useful for calculations, but weighing strategy and reaction charging should account for the actual assay and any reported water or solvent content. Finally, buyers should avoid committing to a long-term route before confirming repeat availability and change-control communication with the supplier.

Evaluating Maison Chemical as a Supplier

When I support a sourcing discussion at Maison Chemical, I focus on matching the product and documentation package to the buyer’s actual use case. I can discuss 2-Chlorophenylboronic acid CAS 3900-89-8, required quantity, packaging preferences, documentation needs, and destination-market considerations. Specific availability, commercial terms, minimum order quantity, and lead time should be confirmed for each inquiry rather than presented as universal commitments.

A practical supplier evaluation should include responsiveness, clarity of specifications, document completeness, packaging suitability, export coordination, and the ability to communicate about repeat orders. Buyers may also ask how the supplier handles lot identification, certificates of analysis, safety data sheets, shipment labeling, and quality questions. These checks help reduce avoidable delays between purchasing, quality assurance, logistics, and the laboratory or production team.

Buyer Checklist Before Ordering

1. Confirm the chemical name, CAS number 3900-89-8, molecular formula, and intended application.
2. Request the current product specification and a batch-specific certificate of analysis where applicable.
3. Review assay, related substances, water, residual solvents, appearance, and identity information.
4. Confirm packaging, labeling, storage guidance, SDS availability, and transport requirements.
5. Ask for quotation details covering quantity, minimum order, lead time, delivery terms, and documentation.
6. Evaluate whether the supplier can support repeat purchasing and communicate relevant quality changes.

Conclusion: Is 2-Chlorophenylboronic Acid CAS 3900-89-8 Suitable for Your Project?

2-Chlorophenylboronic acid CAS 3900-89-8 is a useful aryl boronic acid intermediate when a synthesis requires a 2-chlorophenyl fragment and a coupling-ready boronic acid group. Its approximate molecular weight is 156.37 g/mol, but purchasing decisions should depend on more than molecular data. The appropriate choice requires review of assay, impurity profile, water, documentation, packaging, storage, and supply continuity.

My recommended next step is to prepare a concise inquiry stating the required quantity, application stage, quality limits, destination, documentation expectations, and target delivery window. Maison Chemical can then review the request and provide product and sourcing information subject to confirmation. This process gives technical, purchasing, and quality teams a clearer basis for approving the material and planning future orders.

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