What Is 3,4-Difluoro-2-methoxyphenylboronic Acid CAS 905583-06-4? Properties, Uses, and Supplier Information

I identify 3,4-Difluoro-2-methoxyphenylboronic acid as an organoboron aromatic intermediate used primarily in synthetic chemistry. Its Chemical Abstracts Service number is CAS 905583-06-4, and its molecular formula is commonly represented as C₇H₇BF₂O₃, with a calculated molecular weight of approximately 187.93 g/mol. At Maison Chemical, I position this material for research, process development, and pharmaceutical-intermediate applications where a difluoro-methoxy-substituted arylboronic acid is required.

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This compound is not usually purchased as a finished active pharmaceutical ingredient. Instead, it is selected as a building block for carbon–carbon bond-forming chemistry, especially reactions that introduce a substituted aryl group into a larger molecular structure. Because physical form, purity, residual solvents, and analytical requirements can vary by batch or supplier, I recommend confirming the current specification and certificate of analysis before making a procurement decision.

Quick Summary for Buyers

• Product: 3,4-Difluoro-2-methoxyphenylboronic acid
• CAS number: 905583-06-4
• Molecular formula: C₇H₇BF₂O₃
• Approximate molecular weight: 187.93 g/mol
• Primary role: Arylboronic acid intermediate for synthetic chemistry
• Recommended purchasing approach: Review identity, assay, impurity profile, packaging, and batch documentation before order confirmation

What Is 3,4-Difluoro-2-methoxyphenylboronic Acid?

3,4-Difluoro-2-methoxyphenylboronic acid is an aromatic boronic acid containing three important structural features: an aryl ring, two fluorine substituents, and a methoxy group. The boronic acid functionality provides a reactive handle that can participate in coupling chemistry, while the fluorine and methoxy substituents influence the electronic and steric characteristics of the resulting product. This combination makes the compound useful when a project requires a substituted aromatic fragment rather than an unsubstituted phenyl group.

In practical terms, I would describe it as a specialized pharmaceutical and fine-chemical intermediate rather than a general-purpose commodity reagent. Its value depends on the target molecule, the selected reaction conditions, and the required control of regioisomeric or organic impurities. The CAS number helps buyers distinguish this material from related fluoro- or methoxy-substituted phenylboronic acids with similar names.

Identity and Structural Information

Core Functions and Chemical Value

The main synthetic function of this compound is to serve as an arylboronic acid partner in palladium-catalyzed cross-coupling, including Suzuki-type reactions. In a typical application, the boronic acid group reacts with a suitable aryl or heteroaryl halide to form a new carbon–carbon bond. The boronic acid group is then removed from the final product during the coupling process, leaving the difluoro-methoxy aryl fragment incorporated into the target structure.

The 3,4-difluoro substitution pattern can alter lipophilicity, metabolic behavior, and electronic properties in a medicinal chemistry program. The 2-methoxy group may also influence steric orientation and the reactivity of the aromatic ring. I treat these effects as design considerations rather than guaranteed performance advantages, because the actual outcome depends on the complete molecular structure and the reaction system.

Potential Application Scenarios

Pharmaceutical and Medicinal Chemistry Research

Researchers may use this intermediate during the preparation of small molecules containing substituted biaryl or heteroaryl–aryl motifs. It can support analogue synthesis, structure–activity relationship studies, and route exploration when a difluoro-methoxyphenyl group is part of the target design. The compound should be evaluated within the specific reaction sequence rather than assumed to be suitable for every coupling protocol.

Process Development and Scale-Up

Process chemists may assess this material when developing a reproducible route toward an advanced intermediate or candidate compound. At this stage, buyers commonly need more than a product name: they may require batch-to-batch consistency, defined impurity limits, suitable packaging, and documentation that supports internal quality review. I recommend discussing scale, delivery schedule, and analytical expectations before production planning.

Custom Synthesis and Fine Chemicals

Custom synthesis teams may use 3,4-Difluoro-2-methoxyphenylboronic acid as one component in a multi-step route. Its suitability can depend on moisture control, reaction compatibility, and the stability of the boronic acid during storage and handling. For this reason, I advise testing a representative sample before committing to a larger quantity, particularly when the compound is being introduced into a new process.

Types, Forms, and Material Options

Commercial availability may differ in physical form, packaging size, assay specification, and analytical documentation. Some projects need a research-scale quantity for route screening, while others require a larger supply for process development or manufacturing support. I do not recommend choosing solely by price, because a lower-cost material may create additional work if its impurity profile or documentation does not match the project requirements.

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For procurement, I can help buyers define the required material option around application needs. Typical discussion points include target quantity, desired assay, acceptable impurity levels, packaging configuration, storage conditions, and whether a batch-specific certificate of analysis is required. If the requested specification is not fully defined, I suggest starting with the intended reaction and downstream quality requirements.

Key Specifications Buyers Should Confirm

The first specification to confirm is identity, including the product name, CAS number, molecular formula, and analytical method used for release. Buyers should then review assay and related substances, because these factors may influence reaction yield and purification effort. Depending on the application, water content, residual solvents, inorganic residues, and appearance may also be relevant.

I also recommend confirming whether the supplier can provide supporting documents for the exact batch offered. These may include a certificate of analysis, safety data sheet, packing information, and available analytical spectra or chromatographic data. I avoid presenting unverified purity, melting point, solubility, or storage-life values as fixed specifications; those details should come from the current product documentation.

Handling and Storage Considerations

As with many boronic acid intermediates, I recommend following the supplier’s safety data sheet and using appropriate laboratory or production controls. The material should be protected from conditions that could affect its quality, including unsuitable temperature, humidity, contamination, or repeated exposure to air during handling. Exact storage requirements should be confirmed from the batch documentation rather than inferred from the chemical name alone.

How to Select a Supplier

When I evaluate a supplier for CAS 905583-06-4, I focus first on traceability and technical communication. A reliable supplier should be able to confirm the exact identity, available quantity, current specification, lead time, packaging, and documentation before quotation. Clear answers are especially important when the product will be used in a regulated or quality-sensitive development program.

I also consider whether the supplier can support different stages of demand. A research group may need a small package quickly, whereas a process team may require repeat batches with consistent analytical control. Maison Chemical supports buyer discussions around product selection, quotation, documentation, and shipment planning, subject to the specific order quantity and requested specification.

Buyer Checklist

1. Confirm the name and CAS number: 905583-06-4.
2. Check the molecular formula and approximate molecular weight of 187.93 g/mol.
3. Request the current assay and impurity specification.
4. Review the batch-specific certificate of analysis when available.
5. Confirm packaging, storage, shipping conditions, and lead time.
6. Clarify whether a sample or pilot quantity can be supplied before scale-up.

Maison Chemical Supplier Support

At Maison Chemical, I provide B2B supply support for 3,4-Difluoro-2-methoxyphenylboronic acid CAS 905583-06-4 as a pharmaceutical and fine-chemical intermediate. I can discuss the intended application, required quantity, target specification, packaging preference, and documentation needs before preparing a quotation. This approach helps align the offered material with the buyer’s actual synthetic and quality requirements.

I also understand that procurement decisions may involve several stages, from laboratory screening to process development and repeat supply. For that reason, I encourage buyers to share the expected order size, delivery destination, required timeline, and any internal specification they already use. Where the available information is limited, I will keep the quotation and technical discussion conservative and clearly identify items that require confirmation.

Conclusion and Next Steps

3,4-Difluoro-2-methoxyphenylboronic acid CAS 905583-06-4 is a specialized arylboronic acid intermediate with potential value in cross-coupling, medicinal chemistry, process development, and fine-chemical synthesis. Its defining data include the CAS number 905583-06-4, the formula C₇H₇BF₂O₃, and an approximate molecular weight of 187.93 g/mol. The correct purchasing decision depends on verified identity, current batch quality, documentation, handling requirements, and supply continuity.

For a practical next step, I recommend sending Maison Chemical your required quantity, application stage, target assay or impurity limits, packaging preference, and delivery timeline. I can then help confirm availability, provide applicable product documents, and prepare a B2B quotation for evaluation. This gives your team a clear basis for deciding whether the material is suitable for the next stage of your synthesis or procurement plan.

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