3,5-Difluorophenol CAS 2713-34-0: Technical Data, Applications, and Buyer’s Guide

3,5-Difluorophenol, CAS 2713-34-0, is a fluorinated aromatic phenol used primarily as a research and chemical synthesis intermediate. Its molecular formula is C₆H₄F₂O, and its relative molecular mass is approximately 130.09 g/mol. I recommend evaluating this material by confirmed identity, assay, impurity profile, packaging, documentation, and supply continuity rather than by CAS number alone. The final specification should be agreed with the supplier before purchase because appearance, purity, packaging, and lead time may vary by manufacturing route and batch.

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Who This Guide Is For

This guide is intended for pharmaceutical and agrochemical research teams, specialty chemical manufacturers, process development groups, procurement professionals, and distributors sourcing 3,5-Difluorophenol. It is also useful for buyers comparing laboratory quantities with larger production-oriented supply. I focus on technical identity, application fit, supplier evaluation, and practical purchasing decisions.

3,5-Difluorophenol should normally be treated as an industrial or laboratory chemical intermediate rather than as a finished pharmaceutical ingredient. Before using it in a regulated process, I recommend confirming the applicable quality system, analytical method, change-control requirements, and regulatory documentation for the intended market.

Basic Chemical Identity and Context

3,5-Difluorophenol is a phenol derivative containing two fluorine substituents at the 3- and 5-positions of the aromatic ring. The phenolic hydroxyl group can participate in downstream functionalization, while the fluorine atoms can influence the electronic and physicochemical behavior of molecules prepared from the intermediate. These characteristics make the compound relevant to medicinal chemistry and specialty synthesis programs.

Public chemical databases should be used as an initial identity check, not as a substitute for lot-specific quality documents. PubChem identifies the compound by CAS RN 2713-34-0 and reports the molecular formula C₆H₄F₂O with a molecular weight of 130.09 g/mol. Buyers can cross-check these identity attributes through the U.S. National Library of Medicine PubChem database and then compare them with the supplier’s certificate of analysis (COA).

Core Technical Data

The molecular weight of 130.09 g/mol is useful for stoichiometric calculations, solution preparation, and estimating material consumption. However, it does not define commercial quality by itself. I advise buyers to request the current SDS and lot-specific COA, including assay method, water content where relevant, residual solvents, related substances, and any agreed limits for inorganic or process-related impurities.

Applications of 3,5-Difluorophenol

Pharmaceutical and Medicinal Chemistry Intermediates

One important use is as a building block in the preparation of more complex fluorinated aromatic compounds. The phenolic group may be converted, protected, or used as a site for further chemical transformation depending on the synthetic route. The resulting products may be investigated in pharmaceutical discovery or process development, but the use of this intermediate does not mean that it is an approved active pharmaceutical ingredient.

For pharmaceutical projects, I recommend assessing not only assay but also the impurity pattern and the ability to reproduce the same quality profile across multiple lots. A development team may require tighter controls than a discovery laboratory, particularly when the intermediate enters a late-stage or regulated manufacturing route.

Agrochemical and Specialty Chemical Synthesis

Fluorinated phenols can also serve as starting materials for specialty molecules used in agrochemical research, functional materials, and other high-value chemical programs. The suitability of 3,5-Difluorophenol depends on the target structure, reaction compatibility, and required impurity control. Buyers should avoid selecting the material solely because it contains fluorine; positional isomerism and functional-group location are critical.

Research and Process Development

Small quantities may be used for route scouting, reaction screening, analytical standard preparation, and process-development experiments. At this stage, a buyer may prioritize fast availability and practical packaging, while a commercial process may prioritize batch consistency, scale-up capacity, and long-term supply planning. I recommend defining these priorities before requesting quotations.

Material and Specification Options

Suppliers may offer 3,5-Difluorophenol in different package sizes and specification levels. Laboratory orders may be measured in grams, while pilot or production planning may involve kilograms or larger quantities, subject to manufacturing capability, transport requirements, and applicable regulations. These quantity ranges should be treated as procurement examples rather than guaranteed stock levels.

Purity is commonly discussed as a percentage, but the appropriate target depends on the reaction and downstream control strategy. For example, a discovery screen may accept a different specification from a process step where a particular impurity could carry forward. I recommend specifying the analytical technique, reporting basis, and acceptance limit instead of requesting “high purity” without a defined number.

Information to Include in a Purchase Specification

• CAS RN: 2713-34-0.
• Formula and molecular mass confirmation: C₆H₄F₂O and approximately 130.09 g/mol.
• Minimum assay, such as a project-defined percentage by an agreed method.
• Limits for identified and unidentified impurities, where required.
• Water content and residual-solvent limits when they affect the process.
• Color, physical state, and packaging requirements, if relevant to handling or release.
• Required documentation, including COA, SDS, batch number, manufacturing date, and retest or review information where provided.

Because phenolic compounds may require controlled handling, I recommend reviewing the supplier’s SDS before purchase and ensuring that the receiving site has suitable ventilation, personal protective equipment, spill procedures, and waste controls. The U.S. Occupational Safety and Health Administration provides general information on hazard communication and SDS management through its Hazard Communication Standard resources. The product-specific SDS remains the controlling document for workplace handling decisions.

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How to Select the Right Grade and Supplier

Step 1: Define the Intended Use

First, I identify whether the material is intended for discovery research, analytical work, process development, registration-supporting development, or routine manufacturing. This classification determines the required documentation, impurity controls, quantity, and delivery schedule. A supplier should be able to understand the use case without requiring disclosure of confidential target-molecule information.

Step 2: Confirm Identity and Analytical Requirements

Next, I compare the CAS number, structure, molecular formula, molecular mass, and supplier specification. If the project is sensitive to regioisomeric impurities, I request an analytical discussion covering chromatographic separation and reporting. The buyer and supplier should agree in advance on how assay and impurities will be measured and reported.

Step 3: Evaluate Scale, Packaging, and Logistics

Quantity should be aligned with the actual project stage. A request for 25 g, 100 g, 1 kg, or 10 kg may involve different packaging, production planning, shipping controls, and commercial terms. I recommend asking for the minimum order quantity, available pack sizes, estimated lead time in business days, shipment origin, and whether a pre-shipment sample or document review is possible.

Step 4: Review Commercial and Quality Risk

Price is only one part of total sourcing cost. A lower unit price may be less attractive if the material has an unsuitable impurity profile, inconsistent documentation, long replenishment time, or limited production visibility. I compare at least the quoted price, MOQ, lead time, payment terms, packaging, transport conditions, quality documents, and communication response time.

Pricing, MOQ, and Lead-Time Considerations

There is no universally reliable public price for 3,5-Difluorophenol because cost changes with purity, quantity, packaging, production schedule, freight, destination, and documentation requirements. Laboratory catalog pricing should not be assumed to represent kilogram-scale pricing. For a meaningful quotation, I provide the required quantity, destination country, target specification, preferred package size, and requested delivery window.

MOQ and lead time are also supplier- and batch-dependent. A stocked laboratory pack may ship faster than a larger custom production order, while a planned kilogram order may require manufacturing and quality-release time. Buyers should request a written quotation that separates material cost, packaging, freight, taxes or duties where applicable, and any analytical or customization charges.

Supplier Evaluation Checklist

When I evaluate a supplier, I look for transparent technical communication and evidence that the supplier understands intermediate sourcing requirements. I do not rely on an unverified claim such as “pharmaceutical grade” unless the supplier defines the specification, quality system, and intended use of that term. The following checklist helps reduce avoidable procurement risk.

• Can the supplier confirm CAS 2713-34-0 and the structure of 3,5-Difluorophenol?
• Is a recent COA available with assay, impurities, and analytical methods?
• Can the supplier provide an SDS appropriate for the shipping destination?
• Are sample, pilot, and larger-volume supply options clearly distinguished?
• Can the supplier explain MOQ, lead time, packaging, and shipment conditions?
• Is there a defined process for handling specification changes or batch deviations?
• Can the supplier support technical questions without making unsupported performance claims?

At Maison Chemical, I support buyers by clarifying the requested specification, quantity, documentation package, packaging format, and delivery destination before preparing a quotation. We can discuss research quantities, larger-volume requirements, and project-specific quality expectations for 3,5-Difluorophenol, subject to current manufacturing and supply availability. Please provide your target assay, impurity limits, quantity, destination, and required delivery date so that we can evaluate the request accurately.

Common Buyer Mistakes

A frequent mistake is treating the CAS number as a complete quality specification. The CAS number helps identify the substance, but it does not define assay, impurity limits, water content, packaging, or batch consistency. Another mistake is selecting a supplier based only on the lowest quoted price without reviewing the COA and SDS.

Buyers should also avoid assuming that a small laboratory pack and a production batch will have identical commercial terms or delivery schedules. If the material may be used in a regulated development program, I recommend requesting documentation requirements at the beginning rather than after the first shipment. Early alignment can reduce the risk of repeating analytical work or qualifying a replacement supplier later.

Summary of Key Buying Points

• 3,5-Difluorophenol is identified by CAS 2713-34-0.
• Its molecular formula is C₆H₄F₂O, with an approximate molecular mass of 130.09 g/mol.
• It is mainly evaluated as a fluorinated aromatic phenol and chemical synthesis intermediate.
• Application suitability depends on the target route, impurity sensitivity, and required documentation.
• Assay, impurity profile, water content, residual solvents, packaging, MOQ, and lead time should be agreed before ordering.
• Supplier SDS and COA review should precede process use and site-level handling decisions.

Conclusion: A Practical Next Step for Buyers

3,5-Difluorophenol CAS 2713-34-0 can be a useful fluorinated building block for pharmaceutical, agrochemical, and specialty chemical synthesis, but the correct purchase decision depends on more than identity and molecular weight. I recommend matching the specification to the reaction, confirming analytical requirements, and comparing suppliers on quality evidence, supply continuity, logistics, and total cost. This approach is more reliable than selecting a product from a catalog description alone.

To request support from Maison Chemical, prepare a concise inquiry containing the required quantity, target purity, impurity limits, packaging preference, destination, and delivery schedule. We can then review the technical and commercial requirements and determine whether a standard supply option or a project-specific evaluation is more appropriate.

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